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Patient and provider views on biosimilars to treat breast cancer Posted 10/05/2019

A Canadian breast cancer advocacy group collected insights from patients and medical oncologists regarding the use of biosimilar treatments.

Biosimilars have been available in Canada since 2009 [1]. An increasing number of biosimilars are likely to be approved for use in cancer treatment in the near future, in particular for breast cancer as patents for breast cancer treatments are among the first to expire. The Canadian Breast Cancer Network (CBCN) conducted two virtual roundtables, one with seven breast cancer patients and one with six oncologists to explore key considerations regarding the use of biosimilars. The results are discussed in the white paper, Breast Cancer & Biosimilars Recommendations on Use, Implementation and Patient Communications.

Patient perspectives
Key issues arising from discussions with patients include:
• Lack of confidence in biosimilars. There was a general feeling of distrust in biosimilars, partly due to their name. The awareness that biosimilars are similar to the originator biologicals rather than identical raised concerns that biosimilars were a ‘second-class’ treatment.
• Treatment efficacy and side effects. Patients felt that potentially fatal diseases should be subject to a more stringent review process, and lost confidence over the lack of original clinical research for biologicals. The group had concerns about the side effects arising from switching, and about the extrapolation of data used in the approval process for a biosimilar.
• Communication with patients. Patients felt strongly that they should be kept informed about their treatment. Anxiety levels were raised considerably at the thought of being switched to a biosimilar, although patients claimed that they would follow the advice of their oncologist.
• Need for guiding principles for the use of biosimilars in breast cancer treatment. Patients felt that treatment of breast cancer with biosimilars requires consideration of parameters including type of breast cancer, stage, whether the cancer is recurrent, and age of the patient. Patients were unanimously opposed to the idea of interchangeability for biosimilars.
• Application of cost savings. Patients hoped that savings associated with use of biosimilars would be invested into breast cancer research or used to increase access to existing treatments.

Physician perspectives
Key issues arising from discussions with physicians include:
• Experience and comfort in use. Physicians had different levels of awareness about biosimilars and their use, including their place in breast cancer treatment. Some physicians were not comfortable with extrapolating data from the metastatic setting to the curative one.
• Implementation. Physicians felt strongly about a number of issues, including opposition to switching; using monitoring or post-marketing surveillance of biosimilars to increase industry confidence; the importance of naming conventions and computer coding for pharmacovigilance; and biosimilar manufacturers creating patient support programmes.
• Communication with patients. There was considerable debate among the oncologists around how much and what to tell patients about prescribing a biosimilar. The physicians agreed that until biosimilars are a ‘standard of care’ their use should be communicated to patients.
• Cost implications. Physicians were more focused on long-term savings than short-term ones, noting that savings should not be used to guide treatment decisions.

Biosimilar manufacturers are taking steps to support patients using biosimilars. Biosimilars Canada, an association representing Canada’s biosimilar manufacturers, plans to launch a patient support platform in 2019 that can be customized to meet the individual needs of the therapy, the biosimilar sponsor and payers [2].

Related article
Recommendations published by Canadian breast cancer advocacy group

Reference
1. GaBI Online - Generics and Biosimilars Initiative. Biosimilars approved in Canada [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 May 10]. Available from: www.gabionline.net/Biosimilars/General/Biosimilars-approved-in-Canada  
2. GaBI Online - Generics and Biosimilars Initiative. Biosimilars makers in Canada to launch patient support programme [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 May 10]. Available from: www.gabionline.net/Biosimilars/General/Biosimilars-makers-in-Canada-to-launch-patient-support-programme

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Comments (12)

DR AGBONHALE IS A GOOD MAN posted 13/11/2019 - by jefferson

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clara posted 12/11/2019 - by clararose2128@gmail.com

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clara posted 12/11/2019 - by clararose2128@gmail.com

This is real take it serious, who will believe that a herb can cure HERPES DISEASE in my body, i never believe that this will work i have spend a lot when getting drugs from the hospital to keep me healthy, what i was waiting for is death because i was broke, one day i hard about this great man who is well know of HIV,cancer and herpes cure, i decided to email him, unknowingly to me that this will be the end of the HERPES DISEASE, he prepare the herb for me, and give me instruction on how to take it, at the end of the week which was seven days,he told me to go to the hospital for a check up, and i went surprisingly after it the doctor confirm me cure from HERPES disease I thought it was a joke, i went to other hospital the doctor there also confirm me cure from HERPES disease then i took my friend who was also HERPES patient to the Doctor after the taking of the herbs she was also confirm cure from HERPES disease .please I want every one with this virus to be free, that is why am dropping his email address,(drodukuherbalhealingcentre@gmail.com or his whatsap contact +2348124765093) you can visit his website https://drodukuherbalhealingcentre.weebly.com  https://dr-oduku-herbal-healing-centre.business.site i want you to email him he is a great man. thank you for saving my life, and I promise I will always testify for your good work. you can also reach me clararose2128@gmail.com

how to cure cancer completely without any side effect or harm posted 10/11/2019 - by clara david

WHAT A GREAT MIRACLE THAT I HAVE EVER SEE IN MY LIFE. My names are Clara David I’m a citizen of USA, My younger sister was sicking of breast cancer and her name is Sandra David I and my family have taking her to all kind of hospital in USA still yet no good result. I decided to go to the internet and search for cancer cure so that was how I find a lady called peter Lizzy she was testifies to the world about the goodness of a herbal man who has the roots and herbs to cure all kind of disease and the herbal man email was there. So I decided to contact the herbal man @herbalist_sakura for my younger sister help to cure her breast cancer. I contacted him and told him my problem he told me that I should not worry that my sister cancer will be cure, he told me that there is a medicine that he is going to give me that I will cook it and give it to my sister to drink for one week, so I ask how can I receive the cure that I am in USA, he told me That I will pay for the delivery service. The courier service can transport it to me so he told me the amount I will pay, so my dad paid for the delivery fee. two days later I receive the cure from the courier service so I used it as the herbal man instructed me to, before the week complete my sister cancer was healed and it was like a dream to me not knowing that it was physical I and my family were very happy about the miracle of Doctor so my dad wanted to pay him 5 million us dollars the herbal man did not accept the offer from my dad, but I don't know why he didn't accept the offer, he only say that I should tell the world about him and his miracle he perform so am now here to tell the world about him if you or your relative is having any kind of disease that you can't get from the hospital please contact dr.sakuraspellalter@gmail.com or whats app him +2348110114739 / via his website https://drsakuraspellalter.weebly.com/ you can follow him up on Instagram @herbalist_sakura for the cure, he will help you out with the problem. And if you need more information about the doctor you can mail me davidclara223@gmail.com 

how dr agbonhale help me posted 09/11/2019 - by jefferson

How can I explain this to the world that there is a man who can cure HERPES, I was diagnosed for the past 5 mouth I have being into HERPES since 5 mouth, so I decide to look for help in the internet then I found a post write about this great man called DR. Agbonhale , people say good thing about him that this man have cured, a lot of people in the internet, him has power's to cure HSV1 AND HSV2 I don’t believe that there is a cure for Herpes Simplex Virus because though there is no cure for herpes that what I have in mind HERPES had no cure well , my HERPES is negative through the using of herbal cured of dr agbonhale , I contacted this man for help because of what i see in the internet. if you need his cured just email him now on dragbonhaleherbalhome@gmail.com , thank you DR. i will never stop shearing you testimony DR. Agbonhale . him Can as well CURE THE FOLLOWING DISEASE:-1, HIV/AIDS, 2, Diseases of the hear 3, Malignant tumors 4. Cardiovascular diseases 5. Diabetes mellifluous 6.Influenza and pneumonia 7.Alzheimer's disease 8. hsv1 - hsv2. If you need LOVE SPELL. E.T.C contact him dragbonhaleherbalhome@gmail.com or you whatsapp him on +2349073130326 '';  

herpes cure posted 30/10/2019 - by joy nelson

Herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it, I have read about DR OKOSUN the great herbalist doctor who cure me from herpes with his powerful herbal medicine. i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via UPS SPEED POST and it got to me after 3 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! its really like a dream but i am so happy! for the people suffering from the following diseases, Cancer, hypothyroidism, Herpes, COPD, HIV, Arthritis, Hpv, Infections,Liver Disease, Autoimmune Diseases, Parkinson's disease,Lupus and more should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit. i sent him what he requested and he sent me his medicine which i took for 3 good weeks and today am out here with negative result. when i went for test i was so happy after going through his medication. you can reach him through his email drokosun55@gmail.com or  whatsapp number:+2348124363791  

HERPES CURE posted 30/10/2019 - by joy nelson

Herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it, I have read about DR OKOSUN the great herbalist doctor who cure me from herpes with his powerful herbal medicine. i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via UPS SPEED POST and it got to me after 3 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! its really like a dream but i am so happy! for the people suffering from the following diseases, Cancer, hypothyroidism, Herpes, COPD, HIV, Arthritis, Hpv, Infections,Liver Disease, Autoimmune Diseases, Parkinson's disease,Lupus and more should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit. i sent him what he requested and he sent me his medicine which i took for 3 good weeks and today am out here with negative result. when i went for test i was so happy after going through his medication. you can reach him through his email drokosun55@gmail.com or  whatsapp number:+2348124363791  

How i got cured posted 26/10/2019 - by Ruth fraser

Hello everyone. Dr. Osalu Herbs is a good remedy for herpes Virus , I was a carrier of herpes virus  and I saw a testimony on how Dr. Osalu cure Herpes Virus, I decided to contact him, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health. After he finish he sent me the herbs which i took for 2 weeks before asking me to go for a check up and getting there i could not believe that i was confirm HSV 2 Negative after the test,Today i am so happy because i'm free from herpes disease with the help of Dr. Osalu  Thank God now everything is fine, I'm cured by Dr. Osalu herbal medicine, I'm very thankful to God for making it possible. you can reach him on his email, i strongly recommend him to any one out here looking for a cure . drosaluherbalhome@gmail.com or call/whatsapp +2348078668950.     

HIV CURE posted 22/10/2019 - by MORGAN

Greetings to the general public, I want to tell about how I was cured of HIV disease by a Doctor called Dr. voodoo . I was browsing the Internet searching for remedy on HIV and I saw a comment of people talking about how Doctor voodoo cured them. I was scared because I never believed in the Internet but i was convince to give him a try because i having no hope of been cured of HIV so I decided to contact him with his email that was listed on the comment voodoospelltemple66@gmail.com when I contacted him he gave me hope and send a Herbal medicine to me that I took and it seriously worked for me, am a free person now without problem, my HIV result came out negative. I pray for you Dr. voodoo God will give you everlasting life, you shall not die before your time for being sincere and great men. Am so happy, you can also contact him if you have any problem Email: voodoospelltemple66@gmail.com or Add him up on WhatsAp +2348140120719

how i was cure from herpes with the help of dr edidia herbal product posted 09/10/2019 - by rosesharon

Herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it,  I have read about DR EDIDIA the great herbalist doctor who cure me from herpes  with his powerful herbal medicine.  i contacted him to know how he can help me and he told me never to worrythat he will help me with the natural herbs from God!after 2 days of contacting him, he told me that the cure has been ready andhe sent it to me via UPS SPEED POST and it got to me after 3 days!i used the medicine as he instructed me (MORNING and EVENING) and i wascured!its really like a dream but i am so happy!   for the people suffering from the following diseases, Cancer, hypothyroidism, Herpes, COPD, HIV, Arthritis, Hpv, Infections,Liver Disease, Autoimmune Diseases, Parkinson's disease,Lupus Canker sore and more should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit.  i sent him what he requested and he sent me his medicine which i took for 3 good weeks and today am out here with negative result. when i went for test i was so happy after going through his medication. you can reach him through his email dredidiaherbalhome@gmail.com or call whatsapp number:+2349074505296 he will help you out.  here is the Dr website http://dredidiaherbalhome.weebly.com/ https://dr-edidia-herbal-home.business.site/ also visit my facebook pages https://www.facebook.com/dredidiaherbs/?modal=admin_todo_tour OR https://www.facebook.com/HIV-CURE-1359918664158191/?modal=admin_todo_tour  blogs pages https://naturaltreatmentherpes.blogspot.com/ https://besherpestreatment.blogspot.com/ I,m rosesharon and you can get intouch with me via rosesharon915@gmail.com  also view website to know him.

how i got cured posted 02/10/2019 - by alice hollis

Hello everyone, Words cannot describe how happy i am today after been cured from the cancer disease that i have be suffering from over 4 years now. I was diagnose with cancer and i have be living in shame and hiding it, but it became worse that i was searching for cure from different means so desperate until i met with a lady online who was testifying about this herbal doctor called Dr oriane. Who said she get her cancer disease cured with the use of Dr oriane herbal medicine. I never believed but i have to give a try because i was desperately in need of cure to the deadly disease that i have been living with. So i contacted him and we discussed how to get the cure and Dr oriane told me that he had cured with herbal medicine which i will order for and it will be delivered to me. Which i did what he wanted and to my greatest surprise the herbal medicine was delivered to me at my address which i gave to him, with instruction on how to apply was also given to me by Dr oriane. Then i started to use the herbal medicine, so after four weeks of using the herbal medicine, i saw physical changes and went for test at two separates hospitals and i was totally cured, i am here to say thanks to you again Dr oriane for saving me from the deadly cancer disease. Anyone with such disease can also contact Dr oriane through his EMAIL: droriane6@gmail.com.  

cue posted 22/09/2019 - by mary johnson

ALL THANKS TO DR OSO WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM BREAST CANCER.  I'm here again to appreciate. DR OSO God will always continue to bless you more abundantly, for the good works you don in my life, I will always keep on writing good and posting my testimonies about you on the Internet, I’m MARY JOHNSON from TEXAS . I was tested breast cancer positive, I saw a blog on how DR OSO cured people with his herbal portion, i did not believe in natural medicine but i just decided to give him a try, I contacted him,and explain my situation to him,few day later he sent me the herb, after taking DR OSO  herbal medicine for few weeks i went to hospital for check up so luckily i was healed  with his herbal portion, i am so happy. If you have any type of cancer problem or you are also infected with any kind of disease, contact him drosohaberhome@gmail.com or call/whatapp +2348162084839 for advice and for his product,i hope this testimony also help some one out there ..              here is the  dr website. https://sites.google.com/view/drosohaberhome/ His blog page https://drosohaberhome.blogspot.com you can also email me for more info about DR oso  via maryjohnson9700@gmail.com     ALL THANK TO DR OSO .

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