Approaches to increase uptake of biosimilars in Spain

Biosimilars/Research | Posted 13/05/2016 post-comment0 Post your comment

Ainhoa Aranguren Oyarzábal and colleagues from the Madrid Health Service (MHS), Spain, describe approaches that have been introduced in Spain to try and improve uptake of biosimilars in the country [1].

Biological 143606710 V14J14ct

The Assistance Direction of Pharmaceutical Management (ADPM), which comes under the General Authority of Healthcare Coordination, is the department of MHS in charge of making decisions about the region’s strategic plans regarding drugs and medical devices.

In 2010, the ADPM established a strategic approach to improve the uptake of biosimilars in the region. Biosimilars use was monitored via the use of indicators, which were included in the Contract Plan – an agreement signed between the MHS and hospitals in the region. In 2014, the indicator %Biosimilar Drugs Cost Value was included; and in 2016 the percentage of patients on infliximab biosimilar (new patients) was included.

The ADPM also implemented other approaches to try and increase uptake of biosimilars.

One approach was a first Framework Agreement, which was set up for somatropin in 2010. A second agreement was reached in 2014 and is still in effect. In this process, all somatropin brands available on the market (originator and biosimilar) were considered equivalent. The bid price in the Framework Agreement was then set as the price per mg of somatropin (€).

Other indicators have also been established in the Contract Plan, such as annual patient cost for chronic conditions requiring hospital drug dispensing from the hospital pharmacy departments. Somatropin, colony-stimulating factors, erythropoietin and biologicals are dispensed in the hospital pharmacy departments in Spain. Annual patient cost indicators have been established for human growth hormone patients (both adult and paediatric), rheumatoid arthritis, inflammatory bowel disease, psoriasis and cancer patients who need colony-stimulating factors. Each of these indicators also has an established annual standard cost that should be achieved. In this scenario, the prescription and dispensing of biosimilars help hospitals to stay within the annual standard costs laid down in the Contact Plan.

Finally, information flow in the healthcare system is an essential tool and a good quality flow of information is pursued in the MHS. The ADPM has an information database which provides sources of quantitative drug information for hospital. These include: 

  • Files containing information on all hospital drug procurements (obtained monthly).
  • Information about drugs being dispensed to ambulatory patients in each hospital pharmacy department (monthly).
  • Pharmacy-related indicators (three monthly). 

The information in the ADPM information system can be analysed and compared or even cross-referenced with other databases, e.g. drug consumption in the primary care setting. The information system also allows comparative information to be sent to hospitals. This allows hospitals to know their own information such as indicators, drug purchase information, and see how they are positioned with respect to the regional average.

Acknowledgement
This article is prepared based on the paper entitled ‘Best practice to improve biosimilars uptake: the experience of Madrid, Spain’ by Aranguren Oyarzábal A, López Centeno B, Alonso Castro V, Calvo Alcántara MJ, Cruz Martos E, Assistance Direction of Pharmaceutical Management, Madrid Health Service, Spain

Editor’s comment
Readers interested to learn more about market uptake of biosimilars are invited to visit www.gabi-journal.net to view the following manuscript published in GaBI Journal:

Product naming, pricing, and market uptake of biosimilars

Readers interested in contributing a research or perspective paper to GaBI Journal – an independent, peer reviewed academic journal – please send us your submission here.

Related articles
Improvement in uptake of biosimilars in Spain

Uptake of biosimilars increasing in Spain

A strategic approach to increase uptake of biosimilars in Spain

Improving uptake of biosimilars in Spain

Reference
1. Derbyshire M. Improving biosimilars uptake: experience gained in Madrid, Spain. Generics and Biosimilars Initiative Journal (GaBI Journal). 2016;5(2):89-91. doi:10.5639/gabij.2016.0502.021

Permission granted to reproduce for personal and non-commercial use only. All other reproduction, copy or reprinting of all or part of any ‘Content’ found on this website is strictly prohibited without the prior consent of the publisher. Contact the publisher to obtain permission before redistributing.

Copyright – Unless otherwise stated all contents of this website are © 2016 Pro Pharma Communications International. All Rights Reserved. 

comment icon Comments (0)
Post your comment
Most viewed articles
About GaBI
Home/About GaBI Posted 06/08/2009
EU guidelines for biosimilars
EMA logo 1 V13C15
Home/Guidelines Posted 08/10/2010